MSG: How safe is it during pregnancy?

Monosodium glutamate (MSG) was shown to penetrate placental barrier and distribute almost evenly among embryonic tissues using 3H-Glu as a tracer, in some research studies. MSG performed its transplacental neurotoxicity (damage to nervous system in the fetus, by crossing the placenta) in a dose-dependent manner. The excessive activation of Glu receptors and the overloading of intracellular Ca2+ induced by MSG ultimately leading to neuronal death may result in the reduction of the capability of learning and memory in adult filial mice treated with MSG, during pregnancy.

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